Karrie graduated in 1992 from Rice University with degrees in Biology and French Literature. She started in a PhD program in Microbiology at UC Davis, but quickly decided that this was not the right path for her. She moved to Bakersfield, CA to operate an ill-fated movie theater with then-boyfriend Tim League. In 1995 Tim and Karrie got married, relocated to Austin and co-founded the Alamo Drafthouse Cinema. She was responsible for most of the behind-the-scenes business functions of the theater until 2010. After stepping away from this role in recent years, she has returned to work in 2019 to facilitate the creation of a Sustainability Task Force, dedicated to reducing the environmental footprint of the business.